Um what? Potent? How? Where?

New Paper in Tet Lett. (doi:10.1016/j.tetlet.2009.12.089  ) “Synthesis of biologically potent new 3-(heteroaryl)aminocoumarin derivatives via Buchwald–Hartwig C–N coupling” so you’d think there some er, biological data there somewhere. Oh yes here it is:

Furthermore, 10 synthesized 3-(heteroaryl)aminocoumarins were assessed to evaluate their bioactivities involving 3D-QSAR techniques. The result showed that compound (3g) may prevent cell proliferation by inhibiting transmembrane transduction cell pathways while compound (3i) may be a promise against endocrine dependent cancer. In addition compound (3b) and (3c) have aromatase inhibitory activities and HIV-1 inhibitory activities with high cytotoxicity to MT-2 cell lines.

That’s it. No data no assays to show the how and why. And this gets in TL these days?


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About martin

almost on holidays
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