A bit old news now, but definitely generating interest in our Mac-heavy workplace is the news that Sybyl 8.1 is now available on the Mac (Under X-Windows):
I’ve tried it a bit and so far so good. But like most installations, you will need admin access to your machine to get it set up the way you want it. Not such an easy task in Uni setups these days where admin/root is given out about as freely as oh, second PhD’s.
Tripos International Announces Availability of its Popular SYBYL® Molecular Modeling Environment for the Mac.